AP1AR

Official Symbol: AP1AR
Official Name: adaptor related protein complex 1 associated regulatory protein
Aliases and Previous Symbols: N/A
Entrez ID: 55435
UniProt: Q63HQ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus- end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo- lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vesicle targeting, trans-Golgi to endosome
negative regulation of receptor recycling
AP-1 adaptor complex binding
negative regulation of substrate adhesion-dependent cell spreading
regulation of Arp2/3 complex-mediated actin nucleation
Golgi to endosome transport
regulation of receptor recycling
regulation of actin nucleation
kinesin binding
regulation of substrate adhesion-dependent cell spreading
negative regulation of cell-substrate adhesion
vesicle targeting, to, from or within Golgi
vesicle targeting
transport vesicle
negative regulation of cell morphogenesis involved in differentiation
post-Golgi vesicle-mediated transport
late endosome
cytosolic transport
regulation of actin filament polymerization
establishment of vesicle localization
regulation of actin polymerization or depolymerization
regulation of actin filament length
vesicle localization
regulation of cell-substrate adhesion
regulation of protein polymerization
early endosome
regulation of actin filament organization
endosome
negative regulation of cell adhesion
negative regulation of cell motility
regulation of cell morphogenesis involved in differentiation
negative regulation of cellular component movement
negative regulation of locomotion
negative regulation of cell development
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
establishment of organelle localization
Golgi vesicle transport
regulation of cellular component size
regulation of actin filament-based process