AP3M2

Entrez Summary: N/A
UniProt Summary: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Clat adaptor s
Adap comp sub

AP-type membrane coat adaptor complex
clathrin adaptor complex
synaptic vesicle cytoskeletal transport
anterograde synaptic vesicle transport
synaptic vesicle transport along microtubule
synaptic vesicle transport
synaptic vesicle localization
anterograde axonal transport
vesicle transport along microtubule
vesicle cytoskeletal trafficking
axonal transport
axon cytoplasm
axo-dendritic transport
organelle transport along microtubule
cytoplasmic vesicle membrane
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
microtubule-based movement
establishment of organelle localization
organelle localization
microtubule-based process
Golgi apparatus
intracellular protein transport
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport