APLNR

Gene Information

Official Symbol: APLNR
Official Name: apelin receptor
Aliases and Previous Symbols: N/A
Entrez ID: 187
UniProt: P35414
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)- derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:P79960, ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10578
Expression level (log2 read counts): -7.68

Expression Distribution

positive regulation of inhibitory G protein-coupled receptor phosphorylation
apelin receptor activity
regulation of inhibitory G protein-coupled receptor phosphorylation
apelin receptor signaling pathway
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
adult heart development
negative regulation of cAMP-mediated signaling
positive regulation of sprouting angiogenesis
positive regulation of release of sequestered calcium ion into cytosol
coronary vasculature development
regulation of cAMP-mediated signaling
positive regulation of calcium ion transport into cytosol
vasculogenesis
regulation of sprouting angiogenesis
positive regulation of calcium ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
positive regulation of endothelial cell proliferation
regulation of calcium ion transport into cytosol
positive regulation of calcium ion transport
regulation of sequestering of calcium ion
regulation of endothelial cell proliferation
positive regulation of cation transmembrane transport
regulation of G protein-coupled receptor signaling pathway
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
gastrulation
positive regulation of angiogenesis
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
positive regulation of transmembrane transport
signaling receptor activity
regulation of calcium ion transport
positive regulation of ion transport
positive regulation of cytosolic calcium ion concentration
regulation of angiogenesis
angiogenesis
regulation of vasculature development
regulation of cytosolic calcium ion concentration
regulation of epithelial cell proliferation