APOA1BP

Entrez Summary: The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:27616477}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NADHX epimerase activity
NADPHX epimerase activity
NAD biosynthesis via nicotinamide riboside salvage pathway
NAD biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
nucleotide binding
cell body
protein homotetramerization
coenzyme biosynthetic process
protein tetramerization
cilium
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
protein homooligomerization
mitochondrial matrix
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
protein complex oligomerization
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
intracellular membrane-bounded organelle
protein homodimerization activity
organophosphate metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
protein-containing complex assembly
extracellular space