APOA2
Gene Information
- Official Symbol: APOA2
- Official Name: apolipoprotein A2
- Aliases and Previous Symbols: N/A
- Entrez ID: 336
- UniProt: P02652
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008].
- UniProt Summary: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Pfam Domains GO Terms
Pfam Domains
| ApoA-II |
GO Terms
| negative regulation of cholesterol transporter activity |
| negative regulation of lipid transporter activity |
| negative regulation of cholesterol import |
| regulation of cholesterol transporter activity |
| negative regulation of sterol import |
| negative regulation of very-low-density lipoprotein particle remodeling |
| apolipoprotein receptor binding |
| high-density lipoprotein particle receptor binding |
| regulation of lipid transporter activity |
| diacylglycerol catabolic process |
| regulation of sterol import |
| regulation of cholesterol import |
| regulation of very-low-density lipoprotein particle remodeling |
| negative regulation of cytokine secretion involved in immune response |
| phosphatidylcholine-sterol O-acyltransferase activator activity |
| lipase inhibitor activity |
| regulation of intestinal cholesterol absorption |
| regulation of intestinal lipid absorption |
| spherical high-density lipoprotein particle |
| positive regulation of cholesterol esterification |
| regulation of intestinal absorption |
| chylomicron remodeling |
| high-density lipoprotein particle clearance |
| high-density lipoprotein particle binding |
| chylomicron assembly |
| regulation of cholesterol esterification |
| negative regulation of cholesterol transport |
| phospholipid efflux |
| positive regulation of interleukin-8 biosynthetic process |
| negative regulation of sterol transport |
| high-density lipoprotein particle assembly |
| protein oxidation |
| chylomicron |
| low-density lipoprotein particle remodeling |
| peptidyl-methionine modification |
| triglyceride-rich lipoprotein particle remodeling |
| regulation of interleukin-8 biosynthetic process |
| reverse cholesterol transport |
| regulation of cytokine secretion involved in immune response |
| negative regulation of lipase activity |
| cholesterol transfer activity |
| high-density lipoprotein particle remodeling |
| very-low-density lipoprotein particle |
| diacylglycerol metabolic process |
| high-density lipoprotein particle |
| negative regulation of lipid catabolic process |
| cholesterol efflux |
| positive regulation of lipid catabolic process |
| negative regulation of cytokine production involved in immune response |
| negative regulation of lipid transport |
| plasma lipoprotein particle assembly |
| positive regulation of steroid metabolic process |
| phosphatidylcholine binding |
| plasma lipoprotein particle remodeling |
| protein-lipid complex remodeling |
| protein-containing complex remodeling |
| lipid transporter activity |
| protein-lipid complex assembly |
| phosphatidylcholine biosynthetic process |
| negative regulation of production of molecular mediator of immune response |
| neutral lipid catabolic process |
| acylglycerol catabolic process |
| phospholipid catabolic process |
| regulation of digestive system process |
| plasma lipoprotein particle clearance |
| negative regulation of lipid localization |
| plasma lipoprotein particle organization |
| regulation of cholesterol transport |
| regulation of sterol transport |
| protein-lipid complex subunit organization |
| positive regulation of interleukin-8 production |
| cholesterol binding |
| glycerolipid catabolic process |
| cholesterol transport |
| regulation of lipid catabolic process |
| heat shock protein binding |
| sterol transport |
| positive regulation of cytokine biosynthetic process |
| negative regulation of cytokine secretion |
| positive regulation of phagocytosis |
| regulation of interleukin-8 production |
| acute inflammatory response |
| regulation of plasma lipoprotein particle levels |
| animal organ regeneration |
| triglyceride metabolic process |
| response to estrogen |
| phosphatidylcholine metabolic process |
| negative regulation of transporter activity |
| cholesterol homeostasis |
| sterol homeostasis |
| negative regulation of lipid metabolic process |
| regulation of cytokine production involved in immune response |
| phospholipid transport |
| regulation of phagocytosis |
| regulation of lipase activity |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| retinoid metabolic process |
| phospholipid binding |
| regulation of cytokine biosynthetic process |
| regulation of lipid transport |
| diterpenoid metabolic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| lipoprotein metabolic process |
| terpenoid metabolic process |
| negative regulation of immune effector process |
| organophosphate ester transport |
| organophosphate catabolic process |
| secondary alcohol metabolic process |
| negative regulation of protein secretion |
| lipid homeostasis |
| sterol metabolic process |
| isoprenoid metabolic process |
| organic hydroxy compound transport |
| response to glucose |
| regulation of lipid localization |
| negative regulation of peptide secretion |
| regulation of production of molecular mediator of immune response |
| blood microparticle |
| positive regulation of lipid metabolic process |
| response to hexose |
| response to glucocorticoid |
| negative regulation of immune response |
| response to monosaccharide |
| lipid binding |
| regeneration |
| response to corticosteroid |
| response to carbohydrate |
| protein stabilization |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| ammonium ion metabolic process |
| cellular lipid catabolic process |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| negative regulation of secretion |
| phospholipid biosynthetic process |
| early endosome |
| steroid metabolic process |
| negative regulation of cytokine production |
| regulation of transporter activity |
| regulation of protein stability |
| lipid transport |
| lipid catabolic process |
| endoplasmic reticulum lumen |
| glycerophospholipid metabolic process |
| negative regulation of catabolic process |
| alcohol metabolic process |
| lipid localization |
| response to steroid hormone |
| signaling receptor binding |
| post-translational protein modification |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| extracellular structure organization |
| regulation of lipid metabolic process |
| positive regulation of catabolic process |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| organic hydroxy compound metabolic process |
| organic anion transport |
| regulation of protein secretion |
| regulation of immune effector process |
| negative regulation of transport |
| protein heterodimerization activity |
| regulation of peptide secretion |
| inflammatory response |
| organophosphate biosynthetic process |
| regulation of vesicle-mediated transport |
| lipid biosynthetic process |
| anion transport |
| regulation of system process |
| regulation of cytokine production |
| viral process |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| symbiotic process |
| negative regulation of catalytic activity |
| regulation of secretion |
| interspecies interaction between organisms |
| response to lipid |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| organophosphate metabolic process |
| response to hormone |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| oxidation-reduction process |
| positive regulation of transport |
| regulation of catabolic process |
| response to drug |
| regulation of protein localization |
| chemical homeostasis |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| regulation of hydrolase activity |
| defense response |
| ion transport |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phenformin 20μM R03 exp143 | -2.04 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.422 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17285
- Expression level (log2 read counts): -1.62
Expression Distribution
APOA2 Expression in NALM6 Cells: -1.62
