APOBEC2

Entrez Summary: N/A
UniProt Summary: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:17187054, ECO:0000269|PubMed:21496894}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

APOBEC C
APOBEC N

cytidine deaminase activity
cytidine metabolic process
cytidine to uridine editing
cytidine deamination
cytidine catabolic process
pyrimidine ribonucleoside catabolic process
pyrimidine ribonucleoside metabolic process
DNA demethylation
base conversion or substitution editing
mRNA modification
pyrimidine nucleoside catabolic process
ribonucleoside catabolic process
DNA dealkylation
nucleoside catabolic process
pyrimidine nucleoside metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
demethylation
DNA methylation or demethylation
ribonucleoside metabolic process
DNA modification
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
RNA modification
carbohydrate derivative catabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
mRNA processing
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
mRNA metabolic process
DNA metabolic process
RNA processing
carbohydrate derivative metabolic process
organonitrogen compound catabolic process