APOBEC3A

Entrez Summary: N/A
UniProt Summary: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

APOBEC C
APOBEC N

clearance of foreign intracellular nucleic acids
clearance of foreign intracellular DNA
clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
deoxycytidine deaminase activity
DNA cytosine deamination
cytidine deaminase activity
cytidine to uridine editing
cytidine deamination
cytidine metabolic process
cytidine catabolic process
DNA deamination
pyrimidine ribonucleoside catabolic process
pyrimidine ribonucleoside metabolic process
DNA demethylation
base conversion or substitution editing
pyrimidine nucleoside catabolic process
negative regulation of transposition
regulation of transposition
ribonucleoside catabolic process
DNA dealkylation
nucleoside catabolic process
pyrimidine nucleoside metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
negative regulation of viral genome replication
demethylation
DNA methylation or demethylation
ribonucleoside metabolic process
negative regulation of viral life cycle
DNA modification
regulation of viral genome replication
negative regulation of viral process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
regulation of viral life cycle
RNA modification
cellular response to xenobiotic stimulus
defense response to virus