APPL1

Gene Information

Official Symbol: APPL1
Official Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Aliases and Previous Symbols: N/A
Entrez ID: 26060
UniProt: Q9UKG1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008].
UniProt Summary: Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. {ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:26073777}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16306
Expression level (log2 read counts): 6.17

Expression Distribution

negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of macropinocytosis
regulation of macropinocytosis
intracellular vesicle
positive regulation of melanin biosynthetic process
positive regulation of pinocytosis
positive regulation of secondary metabolite biosynthetic process
adiponectin-activated signaling pathway
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
macropinosome
regulation of melanin biosynthetic process
protein kinase B binding
regulation of pinocytosis
early phagosome
regulation of secondary metabolite biosynthetic process
regulation of Fc receptor mediated stimulatory signaling pathway
regulation of secondary metabolic process
cellular response to hepatocyte growth factor stimulus
positive regulation of cytokine production involved in inflammatory response
response to hepatocyte growth factor
negative regulation of phagocytosis
regulation of toll-like receptor 4 signaling pathway
vesicle membrane
regulation of fibroblast migration
signal transduction in absence of ligand
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of glucose import
beta-tubulin binding
regulation of cytokine production involved in inflammatory response
positive regulation of glucose transmembrane transport
regulation of glucose import
phosphatidylserine binding
regulation of toll-like receptor signaling pathway
regulation of glucose transmembrane transport
phosphatidylinositol binding
insulin receptor signaling pathway
ruffle
regulation of protein localization to plasma membrane
protein import into nucleus
regulation of phagocytosis