APTX

Entrez Summary: This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DcpS C
HIT

DNA-3-diphospho-5-guanosine diphosphatase
single-strand break-containing DNA binding
DNA 5-adenosine monophosphate hydrolase activity
phosphoglycolate phosphatase activity
single strand break repair
mismatched DNA binding
DNA ligation
phosphoprotein binding
damaged DNA binding
double-stranded RNA binding
double-stranded DNA binding
protein N-terminus binding
single-stranded DNA binding
chromatin
response to hydrogen peroxide
double-strand break repair
response to reactive oxygen species
nuclear chromatin
regulation of protein stability
nucleic acid phosphodiester bond hydrolysis
response to antibiotic
dephosphorylation
response to oxidative stress
chromatin binding
response to toxic substance
DNA repair
response to inorganic substance
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
response to drug
response to oxygen-containing compound
cellular response to stress