AQP2 [The Human Chemical-Genetic Interaction Map Project]

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======= AQP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP2
  * **<color #00a2e8>Official Name</color>**: aquaporin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=359|359]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41181|P41181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lumenal side of membrane|
|cellular response to mercury ion|
|glycerol transmembrane transporter activity|
|cellular response to water deprivation|
|cellular response to water stimulus|
|renal water transport|
|water transmembrane transporter activity|
|glycerol transport|
|metanephric collecting duct development|
|response to water deprivation|
|response to mercury ion|
|water channel activity|
|polyol transport|
|collecting duct development|
|response to water|
|water transport|
|fluid transport|
|cellular response to copper ion|
|renal water homeostasis|
|transport vesicle membrane|
|response to copper ion|
|multicellular organismal water homeostasis|
|water homeostasis|
|carbohydrate transport|
|metanephros development|
|protein homotetramerization|
|renal system process|
|recycling endosome|
|organic hydroxy compound transport|
|protein tetramerization|
|cellular response to metal ion|
|basolateral plasma membrane|
|cellular response to acid chemical|
|cellular response to inorganic substance|
|cellular response to extracellular stimulus|
|kidney development|
|renal system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|urogenital system development|
|apical plasma membrane|
|multicellular organismal homeostasis|
|cellular response to external stimulus|
|protein homooligomerization|
|response to acid chemical|
|response to metal ion|
|regulation of body fluid levels|
|protein complex oligomerization|
|response to extracellular stimulus|
|response to inorganic substance|
|tube development|
|Golgi apparatus|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|cellular response to stress|
|protein-containing complex subunit organization|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.76|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10879
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>