AQP4

Entrez Summary: This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
UniProt Summary: Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

astrocyte end-foot
cerebrospinal fluid circulation
cellular water homeostasis
water channel activity
water transport
epithelial cilium movement involved in extracellular fluid movement
fluid transport
cell volume homeostasis
extracellular transport
renal water homeostasis
cilium movement
multicellular organismal water homeostasis
water homeostasis
protein homotetramerization
sarcolemma
renal system process
protein tetramerization
cellular response to interferon-gamma
regulation of cell size
response to interferon-gamma
microtubule-based transport
basolateral plasma membrane
endosome membrane
microtubule-based movement
multicellular organismal homeostasis
protein homooligomerization
regulation of cellular component size
external side of plasma membrane
regulation of body fluid levels
regulation of anatomical structure size
protein complex oligomerization
microtubule-based process
cellular chemical homeostasis
innate immune response
cellular homeostasis
defense response to other organism
cellular response to cytokine stimulus
response to cytokine
chemical homeostasis
transmembrane transport