ARAP1

Gene Information

Official Symbol: ARAP1
Official Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 116985
UniProt: Q96P48
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8441
Expression level (log2 read counts): 6.2

Expression Distribution

ArfGap
SAM 2
RA
RhoGAP
SAM 1
PH

actin filament reorganization involved in cell cycle
type 1 angiotensin receptor binding
actin filament reorganization
positive regulation of receptor recycling
negative regulation of stress fiber assembly
regulation of receptor recycling
negative regulation of actin filament bundle assembly
positive regulation of filopodium assembly
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERBB signaling pathway
phosphatidylinositol-3,4,5-trisphosphate binding
regulation of filopodium assembly
actin cytoskeleton reorganization
regulation of stress fiber assembly
regulation of epidermal growth factor receptor signaling pathway
regulation of actomyosin structure organization
regulation of ERBB signaling pathway
Golgi cisterna membrane
regulation of actin filament bundle assembly
positive regulation of plasma membrane bounded cell projection assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of cell shape
trans-Golgi network
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
actin filament organization
cytoplasmic vesicle
regulation of actin filament organization
GTPase activator activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
negative regulation of organelle organization
positive regulation of cell projection organization
regulation of actin filament-based process
positive regulation of GTPase activity
supramolecular fiber organization
regulation of GTPase activity
regulation of cell morphogenesis