ARFGEF1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARFGEF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARFGEF1
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10565|10565]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6D6|Q9Y6D6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARFGEF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARFGEF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec7 N|
|Sec7|
|DUF1981|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein glycosylation in Golgi|
|regulation of protein glycosylation in Golgi|
|positive regulation of protein glycosylation|
|regulation of protein glycosylation|
|small nuclear ribonucleoprotein complex|
|ARF guanyl-nucleotide exchange factor activity|
|regulation of ARF protein signal transduction|
|positive regulation of glycoprotein biosynthetic process|
|protein kinase A regulatory subunit binding|
|regulation of establishment of cell polarity|
|positive regulation of glycoprotein metabolic process|
|myosin binding|
|regulation of establishment or maintenance of cell polarity|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|negative regulation of GTPase activity|
|negative regulation of actin filament polymerization|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|negative regulation of protein polymerization|
|guanyl-nucleotide exchange factor activity|
|nuclear matrix|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|Golgi organization|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|regulation of actin filament polymerization|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|trans-Golgi network|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of protein kinase B signaling|
|regulation of protein polymerization|
|regulation of Ras protein signal transduction|
|regulation of actin filament organization|
|GTPase activator activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|endomembrane system organization|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|Golgi membrane|
|neuron projection development|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|exocytosis|
|neuron development|
|nucleolus|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|secretion by cell|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|export from cell|
|secretion|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.92|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.74|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.13|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.89|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.532|
|[[:human genes:a:apba3|APBA3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARFGEF1 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>