ARFGEF1

Gene Information

Official Symbol: ARFGEF1
Official Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 10565
UniProt: Q9Y6D6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.92
Vemurafenib 6.6μM R08 exp434	-2.74
Monensin 0.3μM R08 exp507	-2.13
Nicotine 3000μM R08 exp510	-1.89
MSC2530818 10μM R07 exp379	-1.81

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17921
Expression level (log2 read counts): 6.51

Expression Distribution

Gene	Correlation
RUVBL2	0.532
APBA3	0.4

Sec7 N
Sec7
DUF1981

positive regulation of protein glycosylation in Golgi
regulation of protein glycosylation in Golgi
positive regulation of protein glycosylation
regulation of protein glycosylation
small nuclear ribonucleoprotein complex
ARF guanyl-nucleotide exchange factor activity
regulation of ARF protein signal transduction
positive regulation of glycoprotein biosynthetic process
protein kinase A regulatory subunit binding
regulation of establishment of cell polarity
positive regulation of glycoprotein metabolic process
myosin binding
regulation of establishment or maintenance of cell polarity
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
negative regulation of GTPase activity
negative regulation of actin filament polymerization
positive regulation of wound healing
positive regulation of response to wounding
negative regulation of protein polymerization
guanyl-nucleotide exchange factor activity
nuclear matrix
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
Golgi organization
regulation of wound healing
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
positive regulation of protein kinase B signaling
regulation of response to wounding
trans-Golgi network
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein kinase B signaling
regulation of protein polymerization
regulation of Ras protein signal transduction
regulation of actin filament organization
GTPase activator activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction