ARHGAP25

Entrez Summary: N/A
UniProt Summary: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
RhoGAP

phagocytic cup
negative regulation of small GTPase mediated signal transduction
phagocytosis, engulfment
plasma membrane invagination
membrane invagination
actin filament organization
GTPase activator activity
phagocytosis
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
supramolecular fiber organization
regulation of GTPase activity
actin cytoskeleton organization
negative regulation of intracellular signal transduction
endocytosis
actin filament-based process
import into cell
positive regulation of hydrolase activity
membrane organization
cytoskeleton organization
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
negative regulation of response to stimulus
positive regulation of molecular function
regulation of intracellular signal transduction
vesicle-mediated transport