ARHGEF10L

Gene Information

Official Symbol: ARHGEF10L
Official Name: Rho guanine nucleotide exchange factor 10 like
Aliases and Previous Symbols: N/A
Entrez ID: 55160
UniProt: Q9HCE6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3199
Expression level (log2 read counts): -3.35

Expression Distribution

SREBP signaling pathway
cellular response to sterol depletion
response to sterol depletion
ER-nucleus signaling pathway
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
Rho guanyl-nucleotide exchange factor activity
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of Ras protein signal transduction
regulation of actin filament organization
GTPase activator activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
regulation of actin filament-based process
positive regulation of GTPase activity
regulation of GTPase activity
actin cytoskeleton organization
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
actin filament-based process
positive regulation of organelle organization
positive regulation of hydrolase activity
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular component organization
positive regulation of transcription by RNA polymerase II
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress