ARHGEF1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGEF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF1
  * **<color #00a2e8>Official Name</color>**: Rho guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9138|9138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92888|Q92888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601855|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
|RGS-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|G protein-coupled receptor binding|
|Rho guanyl-nucleotide exchange factor activity|
|Rho protein signal transduction|
|regulation of Rho protein signal transduction|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|GTPase activator activity|
|small GTPase mediated signal transduction|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|positive regulation of hydrolase activity|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.64|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.2|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.16|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.12|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.03|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.02|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.96|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.85|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.84|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.83|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.81|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.78|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.77|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.73|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.82|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.92|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.94|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.05|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.1|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.13|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.33|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gna13|GNA13]]|0.736|
|[[:human genes:r:rhoa|RHOA]]|0.561|
|[[:human genes:r:ric8a|RIC8A]]|0.54|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF1 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>