ARHGEF1

Entrez Summary: N/A
UniProt Summary: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM R07 exp306	-2.64
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.2
Cabazitaxel 0.001μM R05 exp223	-2.16
I-BRD9 4μM R07 exp365	-2.12
Epothilone-B 0.0015μM R05 exp231	-2.03
PU-H71 1μM R08 exp515	-2.02
GSK-J4 1μM R07 exp362	-1.96
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.85
Vincristine 0.0005μM R04 exp190	-1.84
Rapamycin 1μM R00 exp29	-1.83
Amiloride 100μM R08 exp447	-1.81
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.78
Rapamycin 10μM R00 exp30	-1.77
Golgicide-A 4μM R03 exp122	-1.73
Thapsigargin 0.005μM R07 exp407	-1.73
BI-6727 0.0125μM R03 exp97	1.82
CR131-b 0.005μM R08 exp474	1.92
TRAIL 50ng/ml R00 exp36	1.94
Aminopterin 0.005μM R07 exp335	2.05
Nicotine 3000μM R08 exp510	2.1
Bafilomycin-A1 0.009μM R08 exp454	2.13
Arsenate 40μM R06 exp264	2.33
Bleomycin 5μM R08 exp459	2.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RhoGEF
RGS-like

G protein-coupled receptor binding
Rho guanyl-nucleotide exchange factor activity
Rho protein signal transduction
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
Ras protein signal transduction
GTPase activator activity
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
positive regulation of hydrolase activity
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
RNA binding
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction