ARHGEF5

Gene Information

Official Symbol: ARHGEF5
Official Name: Rho guanine nucleotide exchange factor 5
Aliases and Previous Symbols: N/A
Entrez ID: 7984
UniProt: Q12774
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16262
Expression level (log2 read counts): -7.68

Expression Distribution

SH3 2
SH3 1
RhoGEF

myeloid dendritic cell chemotaxis
positive regulation of podosome assembly
regulation of podosome assembly
dendritic cell chemotaxis
dendritic cell migration
podosome
cell periphery
positive regulation of protein import
positive regulation of stress fiber assembly
regulation of protein import
positive regulation of actin filament bundle assembly
Rho guanyl-nucleotide exchange factor activity
positive regulation of JUN kinase activity
positive regulation of organelle assembly
regulation of stress fiber assembly
regulation of JUN kinase activity
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
cell projection
guanyl-nucleotide exchange factor activity
myeloid leukocyte migration
positive regulation of JNK cascade
regulation of Rho protein signal transduction
leukocyte chemotaxis
lipid binding
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
positive regulation of supramolecular fiber organization
cell chemotaxis
positive regulation of cytoskeleton organization
regulation of organelle assembly
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
positive regulation of DNA-binding transcription factor activity
positive regulation of MAP kinase activity
regulation of ERK1 and ERK2 cascade