ARHGEF6 [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGEF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF6
  * **<color #00a2e8>Official Name</color>**: Rac/Cdc42 guanine nucleotide exchange factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9459|9459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15052|Q15052]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a RAC1 guanine nucleotide exchange factor (GEF).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
|SH3 1|
|SH3 2|
|CH|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lamellipodium assembly|
|lamellipodium organization|
|Rho guanyl-nucleotide exchange factor activity|
|JNK cascade|
|guanyl-nucleotide exchange factor activity|
|stress-activated MAPK cascade|
|stress-activated protein kinase signaling cascade|
|regulation of Rho protein signal transduction|
|lamellipodium|
|regulation of Ras protein signal transduction|
|GTPase activator activity|
|regulation of small GTPase mediated signal transduction|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of GTPase activity|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of GTPase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|positive regulation of hydrolase activity|
|apoptotic process|
|protein phosphorylation|
|programmed cell death|
|cell death|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF6 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>