ARHGEF6

Entrez Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

lamellipodium assembly
lamellipodium organization
Rho guanyl-nucleotide exchange factor activity
JNK cascade
guanyl-nucleotide exchange factor activity
stress-activated MAPK cascade
stress-activated protein kinase signaling cascade
regulation of Rho protein signal transduction
lamellipodium
regulation of Ras protein signal transduction
GTPase activator activity
regulation of small GTPase mediated signal transduction
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of GTPase activity
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of GTPase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
positive regulation of hydrolase activity
apoptotic process
protein phosphorylation
programmed cell death
cell death
plasma membrane bounded cell projection organization
cell projection organization
regulation of hydrolase activity
phosphorylation
G protein-coupled receptor signaling pathway
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
intracellular signal transduction
cellular response to stress
positive regulation of molecular function
regulation of intracellular signal transduction