ARRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= ARRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARRB2
  * **<color #00a2e8>Official Name</color>**: arrestin beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=409|409]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32121|P32121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arrestin N|
|Arrestin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet activating factor receptor binding|
|follicle-stimulating hormone receptor binding|
|angiotensin receptor binding|
|alpha-1A adrenergic receptor binding|
|type 2A serotonin receptor binding|
|alpha-1B adrenergic receptor binding|
|desensitization of G protein-coupled receptor signaling pathway by arrestin|
|follicle-stimulating hormone signaling pathway|
|negative regulation of smooth muscle cell apoptotic process|
|type 1 angiotensin receptor binding|
|positive regulation of synaptic transmission, dopaminergic|
|arrestin family protein binding|
|D1 dopamine receptor binding|
|protein kinase B binding|
|G protein-coupled receptor internalization|
|negative regulation of natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated immunity|
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|regulation of synaptic transmission, dopaminergic|
|negative regulation of interleukin-12 production|
|negative regulation of leukocyte mediated cytotoxicity|
|desensitization of G protein-coupled receptor signaling pathway|
|negative regulation of release of cytochrome c from mitochondria|
|positive regulation of cardiac muscle cell differentiation|
|detection of temperature stimulus|
|negative adaptation of signaling pathway|
|adaptation of signaling pathway|
|sensory perception of temperature stimulus|
|mitogen-activated protein kinase binding|
|negative regulation of cell killing|
|regulation of smooth muscle cell apoptotic process|
|positive regulation of receptor internalization|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|regulation of androgen receptor signaling pathway|
|negative regulation of interleukin-1 beta production|
|positive regulation of cardiocyte differentiation|
|adult walking behavior|
|14-3-3 protein binding|
|walking behavior|
|positive regulation of epithelial cell apoptotic process|
|negative regulation of interleukin-1 production|
|dopamine receptor signaling pathway|
|regulation of collagen biosynthetic process|
|regulation of cardiac muscle cell differentiation|
|negative regulation of muscle cell apoptotic process|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of toll-like receptor signaling pathway|
|regulation of collagen metabolic process|
|negative regulation of interleukin-6 production|
|ovulation cycle process|
|regulation of natural killer cell mediated cytotoxicity|
|positive regulation of cardiac muscle tissue development|
|regulation of natural killer cell mediated immunity|
|negative regulation of GTPase activity|
|negative regulation of protein kinase B signaling|
|negative regulation of G protein-coupled receptor signaling pathway|
|molecular adaptor activity|
|regulation of release of cytochrome c from mitochondria|
|negative regulation of leukocyte mediated immunity|
|regulation of cardiocyte differentiation|
|ovarian follicle development|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of mitochondrion organization|
|regulation of interleukin-12 production|
|clathrin-coated pit|
|regulation of receptor internalization|
|negative regulation of innate immune response|
|positive regulation of striated muscle cell differentiation|
|endocytic vesicle|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|receptor internalization|
|excitatory postsynaptic potential|
|G protein-coupled receptor binding|
|chemical synaptic transmission, postsynaptic|
|ovulation cycle|
|positive regulation of DNA biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|regulation of muscle cell apoptotic process|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|negative regulation of protein ubiquitination|
|sensory perception of pain|
|regulation of leukocyte mediated cytotoxicity|
|regulation of intracellular steroid hormone receptor signaling pathway|
|adult locomotory behavior|
|regulation of cardiac muscle tissue development|
|regulation of epithelial cell apoptotic process|
|regulation of interleukin-1 beta production|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein modification by small protein conjugation or removal|
|cellular response to dopamine|
|response to dopamine|
|positive regulation of muscle cell differentiation|
|female gonad development|
|negative regulation of cysteine-type endopeptidase activity|
|signal transduction involved in cellular response to ammonium ion|
|development of primary female sexual characteristics|
|negative regulation of response to biotic stimulus|
|regulation of interleukin-1 production|
|Wnt signaling pathway, planar cell polarity pathway|
|regulation of postsynaptic membrane potential|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|regulation of cell killing|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|regulation of striated muscle cell differentiation|
|negative regulation of protein binding|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of peptidyl-serine phosphorylation|
|receptor metabolic process|
|response to monoamine|
|response to catecholamine|
|female sex differentiation|
|regulation of establishment of planar polarity|
|regulation of DNA biosynthetic process|
|positive regulation of protein ubiquitination|
|detection of external stimulus|
|negative regulation of immune effector process|
|positive regulation of calcium ion transport|
|detection of abiotic stimulus|
|cellular response to ammonium ion|
|regulation of striated muscle tissue development|
|non-canonical Wnt signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of peptidyl-serine phosphorylation|
|platelet activation|
|regulation of interleukin-6 production|
|regulation of G protein-coupled receptor signaling pathway|
|negative regulation of neuron apoptotic process|
|adult behavior|
|dendritic spine|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|positive regulation of synaptic transmission|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of muscle cell differentiation|
|cellular response to transforming growth factor beta stimulus|
|negative regulation of DNA-binding transcription factor activity|
|response to transforming growth factor beta|
|positive regulation of protein kinase B signaling|
|negative regulation of binding|
|response to temperature stimulus|
|regulation of mitochondrion organization|
|regulation of morphogenesis of an epithelium|
|response to ammonium ion|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA metabolic process|
|locomotory behavior|
|basolateral plasma membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|postsynaptic membrane|
|regulation of protein ubiquitination|
|regulation of leukocyte mediated immunity|
|regulation of endocytosis|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|negative regulation of defense response|
|cell chemotaxis|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of multi-organism process|
|development of primary sexual characteristics|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|receptor-mediated endocytosis|
|regulation of cysteine-type endopeptidase activity|
|protein domain specific binding|
|negative regulation of endopeptidase activity|
|regulation of calcium ion transport|
|postsynaptic density|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of peptidase activity|
|regulation of animal organ morphogenesis|
|sex differentiation|
|protein-containing complex binding|
|endosome|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|rhythmic process|
|protein deubiquitination|
|blood coagulation|
|ubiquitin protein ligase binding|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|protein modification by small protein removal|
|hemostasis|
|regulation of neuron death|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|signaling receptor binding|
|enzyme binding|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of metal ion transport|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|synaptic signaling|
|regulation of immune effector process|
|wound healing|
|transcription by RNA polymerase II|
|regulation of GTPase activity|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|detection of stimulus involved in sensory perception|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|endocytosis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|response to wounding|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|import into cell|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|detection of stimulus|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|brain development|
|regulation of MAPK cascade|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|head development|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|membrane organization|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.84|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARRB2 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>