ARRB2
Gene Information
- Official Symbol: ARRB2
- Official Name: arrestin beta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 409
- UniProt: P32121
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Arrestin N |
| Arrestin C |
GO Terms
| platelet activating factor receptor binding |
| follicle-stimulating hormone receptor binding |
| angiotensin receptor binding |
| alpha-1A adrenergic receptor binding |
| type 2A serotonin receptor binding |
| alpha-1B adrenergic receptor binding |
| desensitization of G protein-coupled receptor signaling pathway by arrestin |
| follicle-stimulating hormone signaling pathway |
| negative regulation of smooth muscle cell apoptotic process |
| type 1 angiotensin receptor binding |
| positive regulation of synaptic transmission, dopaminergic |
| arrestin family protein binding |
| D1 dopamine receptor binding |
| protein kinase B binding |
| G protein-coupled receptor internalization |
| negative regulation of natural killer cell mediated cytotoxicity |
| negative regulation of natural killer cell mediated immunity |
| detection of temperature stimulus involved in sensory perception of pain |
| detection of temperature stimulus involved in sensory perception |
| regulation of synaptic transmission, dopaminergic |
| negative regulation of interleukin-12 production |
| negative regulation of leukocyte mediated cytotoxicity |
| desensitization of G protein-coupled receptor signaling pathway |
| negative regulation of release of cytochrome c from mitochondria |
| positive regulation of cardiac muscle cell differentiation |
| detection of temperature stimulus |
| negative adaptation of signaling pathway |
| adaptation of signaling pathway |
| sensory perception of temperature stimulus |
| mitogen-activated protein kinase binding |
| negative regulation of cell killing |
| regulation of smooth muscle cell apoptotic process |
| positive regulation of receptor internalization |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| regulation of androgen receptor signaling pathway |
| negative regulation of interleukin-1 beta production |
| positive regulation of cardiocyte differentiation |
| adult walking behavior |
| 14-3-3 protein binding |
| walking behavior |
| positive regulation of epithelial cell apoptotic process |
| negative regulation of interleukin-1 production |
| dopamine receptor signaling pathway |
| regulation of collagen biosynthetic process |
| regulation of cardiac muscle cell differentiation |
| negative regulation of muscle cell apoptotic process |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of toll-like receptor signaling pathway |
| regulation of collagen metabolic process |
| negative regulation of interleukin-6 production |
| ovulation cycle process |
| regulation of natural killer cell mediated cytotoxicity |
| positive regulation of cardiac muscle tissue development |
| regulation of natural killer cell mediated immunity |
| negative regulation of GTPase activity |
| negative regulation of protein kinase B signaling |
| negative regulation of G protein-coupled receptor signaling pathway |
| molecular adaptor activity |
| regulation of release of cytochrome c from mitochondria |
| negative regulation of leukocyte mediated immunity |
| regulation of cardiocyte differentiation |
| ovarian follicle development |
| positive regulation of receptor-mediated endocytosis |
| negative regulation of mitochondrion organization |
| regulation of interleukin-12 production |
| clathrin-coated pit |
| regulation of receptor internalization |
| negative regulation of innate immune response |
| positive regulation of striated muscle cell differentiation |
| endocytic vesicle |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| receptor internalization |
| excitatory postsynaptic potential |
| G protein-coupled receptor binding |
| chemical synaptic transmission, postsynaptic |
| ovulation cycle |
| positive regulation of DNA biosynthetic process |
| regulation of toll-like receptor signaling pathway |
| regulation of muscle cell apoptotic process |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| negative regulation of protein ubiquitination |
| sensory perception of pain |
| regulation of leukocyte mediated cytotoxicity |
| regulation of intracellular steroid hormone receptor signaling pathway |
| adult locomotory behavior |
| regulation of cardiac muscle tissue development |
| regulation of epithelial cell apoptotic process |
| regulation of interleukin-1 beta production |
| negative regulation of NF-kappaB transcription factor activity |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of protein modification by small protein conjugation or removal |
| cellular response to dopamine |
| response to dopamine |
| positive regulation of muscle cell differentiation |
| female gonad development |
| negative regulation of cysteine-type endopeptidase activity |
| signal transduction involved in cellular response to ammonium ion |
| development of primary female sexual characteristics |
| negative regulation of response to biotic stimulus |
| regulation of interleukin-1 production |
| Wnt signaling pathway, planar cell polarity pathway |
| regulation of postsynaptic membrane potential |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| regulation of cell killing |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| regulation of striated muscle cell differentiation |
| negative regulation of protein binding |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of peptidyl-serine phosphorylation |
| receptor metabolic process |
| response to monoamine |
| response to catecholamine |
| female sex differentiation |
| regulation of establishment of planar polarity |
| regulation of DNA biosynthetic process |
| positive regulation of protein ubiquitination |
| detection of external stimulus |
| negative regulation of immune effector process |
| positive regulation of calcium ion transport |
| detection of abiotic stimulus |
| cellular response to ammonium ion |
| regulation of striated muscle tissue development |
| non-canonical Wnt signaling pathway |
| positive regulation of protein modification by small protein conjugation or removal |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of peptidyl-serine phosphorylation |
| platelet activation |
| regulation of interleukin-6 production |
| regulation of G protein-coupled receptor signaling pathway |
| negative regulation of neuron apoptotic process |
| adult behavior |
| dendritic spine |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| positive regulation of synaptic transmission |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of muscle cell differentiation |
| cellular response to transforming growth factor beta stimulus |
| negative regulation of DNA-binding transcription factor activity |
| response to transforming growth factor beta |
| positive regulation of protein kinase B signaling |
| negative regulation of binding |
| response to temperature stimulus |
| regulation of mitochondrion organization |
| regulation of morphogenesis of an epithelium |
| response to ammonium ion |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of DNA metabolic process |
| locomotory behavior |
| basolateral plasma membrane |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| postsynaptic membrane |
| regulation of protein ubiquitination |
| regulation of leukocyte mediated immunity |
| regulation of endocytosis |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| negative regulation of defense response |
| cell chemotaxis |
| gonad development |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of multi-organism process |
| development of primary sexual characteristics |
| regulation of protein binding |
| regulation of protein kinase B signaling |
| negative regulation of apoptotic signaling pathway |
| regulation of protein modification by small protein conjugation or removal |
| receptor-mediated endocytosis |
| regulation of cysteine-type endopeptidase activity |
| protein domain specific binding |
| negative regulation of endopeptidase activity |
| regulation of calcium ion transport |
| postsynaptic density |
| cytoplasmic vesicle |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of peptidase activity |
| regulation of animal organ morphogenesis |
| sex differentiation |
| protein-containing complex binding |
| endosome |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| rhythmic process |
| protein deubiquitination |
| blood coagulation |
| ubiquitin protein ligase binding |
| regulation of ERK1 and ERK2 cascade |
| coagulation |
| protein modification by small protein removal |
| hemostasis |
| regulation of neuron death |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| signaling receptor binding |
| enzyme binding |
| proteasomal protein catabolic process |
| negative regulation of proteolysis |
| cellular process involved in reproduction in multicellular organism |
| regulation of DNA metabolic process |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| negative regulation of response to external stimulus |
| negative regulation of organelle organization |
| regulation of binding |
| regulation of metal ion transport |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| regulation of endopeptidase activity |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| reproductive structure development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| regulation of membrane potential |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| regulation of innate immune response |
| negative regulation of hydrolase activity |
| synaptic signaling |
| regulation of immune effector process |
| wound healing |
| transcription by RNA polymerase II |
| regulation of GTPase activity |
| regulation of body fluid levels |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| response to growth factor |
| modification-dependent protein catabolic process |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| detection of stimulus involved in sensory perception |
| modification-dependent macromolecule catabolic process |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| endocytosis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| behavior |
| response to wounding |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| cellular protein catabolic process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| RNA biosynthetic process |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| import into cell |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| protein ubiquitination |
| detection of stimulus |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| negative regulation of cellular component organization |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| brain development |
| regulation of MAPK cascade |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| head development |
| negative regulation of catalytic activity |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| membrane organization |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| response to organic cyclic compound |
| cell migration |
| positive regulation of cell differentiation |
| sensory perception |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| negative regulation of cell death |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| locomotion |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 2μM R00 exp16 | 1.84 |
| HMS-I2 1μM R06 exp286 | 1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7144
- Expression level (log2 read counts): 6.05
Expression Distribution
ARRB2 Expression in NALM6 Cells: 6.05
