ASAH1

Entrez Summary: This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015].
UniProt Summary: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. {ECO:0000269|PubMed:7744740}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
ceramidase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
N-acylsphingosine amidohydrolase activity
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
sphingoid metabolic process
diol biosynthetic process
ceramide catabolic process
regulation of programmed necrotic cell death
diol metabolic process
regulation of necrotic cell death
sphingolipid catabolic process
membrane lipid catabolic process
ceramide biosynthetic process
tertiary granule lumen
polyol biosynthetic process
glycosphingolipid metabolic process
ceramide metabolic process
regulation of steroid biosynthetic process
sphingolipid biosynthetic process
lysosomal lumen
glycolipid metabolic process
liposaccharide metabolic process
polyol metabolic process
alcohol biosynthetic process
regulation of steroid metabolic process
ficolin-1-rich granule lumen
membrane lipid biosynthetic process
sphingolipid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
cellular response to tumor necrosis factor
lysosome
early endosome
response to tumor necrosis factor