ASIC3 [The Human Chemical-Genetic Interaction Map Project]

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======= ASIC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASIC3
  * **<color #00a2e8>Official Name</color>**: acid sensing ion channel subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9311|9311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHC3|Q9UHC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASIC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASIC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611741|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ASC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enterobactin transmembrane transporter activity|
|enterobactin transport|
|detection of chemical stimulus involved in sensory perception of pain|
|siderophore transport|
|sensory perception of sour taste|
|ligand-gated sodium channel activity|
|sodium channel activity|
|iron coordination entity transport|
|detection of mechanical stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|cation channel activity|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|response to acidic pH|
|detection of mechanical stimulus involved in sensory perception|
|response to pH|
|detection of mechanical stimulus|
|cofactor transport|
|sensory perception of taste|
|iron ion transport|
|sensory perception of pain|
|sodium ion transmembrane transport|
|response to heat|
|detection of external stimulus|
|transition metal ion transport|
|detection of abiotic stimulus|
|organic hydroxy compound transport|
|sodium ion transport|
|sensory perception of mechanical stimulus|
|response to temperature stimulus|
|response to mechanical stimulus|
|monovalent inorganic cation transport|
|organic anion transport|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|perinuclear region of cytoplasm|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASIC3 Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>