ASIC3

Entrez Summary: N/A
UniProt Summary: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

enterobactin transmembrane transporter activity
enterobactin transport
detection of chemical stimulus involved in sensory perception of pain
siderophore transport
sensory perception of sour taste
ligand-gated sodium channel activity
sodium channel activity
iron coordination entity transport
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
cation channel activity
detection of temperature stimulus
sensory perception of temperature stimulus
response to acidic pH
detection of mechanical stimulus involved in sensory perception
response to pH
detection of mechanical stimulus
cofactor transport
sensory perception of taste
iron ion transport
sensory perception of pain
sodium ion transmembrane transport
response to heat
detection of external stimulus
transition metal ion transport
detection of abiotic stimulus
organic hydroxy compound transport
sodium ion transport
sensory perception of mechanical stimulus
response to temperature stimulus
response to mechanical stimulus
monovalent inorganic cation transport
organic anion transport
detection of chemical stimulus involved in sensory perception
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
inorganic cation transmembrane transport
anion transport