ASIC4

Entrez Summary: N/A
UniProt Summary: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. {ECO:0000269|PubMed:10852210}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	-2.08
GSK-J5 1.5μM R08 exp484	-1.72

sodium ion transmembrane transporter activity
sodium channel activity
ion channel activity
behavioral fear response
behavioral defense response
fear response
multicellular organismal response to stress
sodium ion transmembrane transport
sodium ion transport
monovalent inorganic cation transport
inorganic cation transmembrane transport
behavior
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
transmembrane transport
defense response
ion transport
integral component of plasma membrane