ASNS [The Human Chemical-Genetic Interaction Map Project]

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======= ASNS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASNS
  * **<color #00a2e8>Official Name</color>**: asparagine synthetase (glutamine-hydrolyzing)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440|440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08243|P08243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASNS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASNS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Asn synthase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-asparagine biosynthetic process|
|L-asparagine metabolic process|
|asparagine synthase (glutamine-hydrolyzing) activity|
|asparagine biosynthetic process|
|asparagine metabolic process|
|response to methotrexate|
|PERK-mediated unfolded protein response|
|response to antimetabolite|
|response to follicle-stimulating hormone|
|cofactor binding|
|glutamine metabolic process|
|aspartate family amino acid biosynthetic process|
|response to gonadotropin|
|ER-nucleus signaling pathway|
|cellular response to glucose starvation|
|aspartate family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|cellular amino acid biosynthetic process|
|response to antineoplastic agent|
|endoplasmic reticulum unfolded protein response|
|response to amino acid|
|liver development|
|cellular response to unfolded protein|
|hepaticobiliary system development|
|cellular response to topologically incorrect protein|
|cellular response to starvation|
|positive regulation of mitotic cell cycle|
|response to unfolded protein|
|monocarboxylic acid biosynthetic process|
|response to topologically incorrect protein|
|response to starvation|
|alpha-amino acid metabolic process|
|response to mechanical stimulus|
|cellular response to nutrient levels|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to light stimulus|
|cellular amino acid metabolic process|
|cellular response to external stimulus|
|response to acid chemical|
|positive regulation of cell cycle|
|gland development|
|response to radiation|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|cellular amide metabolic process|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of cell death|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to nitrogen compound|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10093
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASNS Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>