ASNS

Entrez Summary: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

L-asparagine biosynthetic process
L-asparagine metabolic process
asparagine synthase (glutamine-hydrolyzing) activity
asparagine biosynthetic process
asparagine metabolic process
response to methotrexate
PERK-mediated unfolded protein response
response to antimetabolite
response to follicle-stimulating hormone
cofactor binding
glutamine metabolic process
aspartate family amino acid biosynthetic process
response to gonadotropin
ER-nucleus signaling pathway
cellular response to glucose starvation
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
response to antineoplastic agent
endoplasmic reticulum unfolded protein response
response to amino acid
liver development
cellular response to unfolded protein
hepaticobiliary system development
cellular response to topologically incorrect protein
cellular response to starvation
positive regulation of mitotic cell cycle
response to unfolded protein
monocarboxylic acid biosynthetic process
response to topologically incorrect protein
response to starvation
alpha-amino acid metabolic process
response to mechanical stimulus
cellular response to nutrient levels
response to endoplasmic reticulum stress
cellular response to extracellular stimulus
carboxylic acid biosynthetic process
organic acid biosynthetic process
response to light stimulus