ASPA [The Human Chemical-Genetic Interaction Map Project]

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======= ASPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASPA
  * **<color #00a2e8>Official Name</color>**: aspartoacylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=443|443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45381|P45381]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AstE AspA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aspartoacylase activity|
|aspartate catabolic process|
|aminoacylase activity|
|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|
|aspartate metabolic process|
|hydrolase activity, acting on ester bonds|
|dicarboxylic acid catabolic process|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|positive regulation of oligodendrocyte differentiation|
|aspartate family amino acid catabolic process|
|regulation of oligodendrocyte differentiation|
|positive regulation of glial cell differentiation|
|oligodendrocyte development|
|aspartate family amino acid metabolic process|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|cellular amino acid biosynthetic process|
|dicarboxylic acid metabolic process|
|myelination|
|alpha-amino acid catabolic process|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|regulation of gliogenesis|
|cellular amino acid catabolic process|
|glial cell differentiation|
|alpha-amino acid metabolic process|
|gliogenesis|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|small molecule catabolic process|
|positive regulation of neurogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|small molecule biosynthetic process|
|regulation of neurogenesis|
|carboxylic acid metabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.86|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.72|
|[[:results:exp302|35°C R06 exp302]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.477|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASPA Expression in NALM6 Cells: 3.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>