ASPA

Entrez Summary: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aspartoacylase activity
aspartate catabolic process
aminoacylase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
aspartate metabolic process
hydrolase activity, acting on ester bonds
dicarboxylic acid catabolic process
central nervous system myelination
axon ensheathment in central nervous system
positive regulation of oligodendrocyte differentiation
aspartate family amino acid catabolic process
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
oligodendrocyte development
aspartate family amino acid metabolic process
oligodendrocyte differentiation
positive regulation of gliogenesis
regulation of glial cell differentiation
cellular amino acid biosynthetic process
dicarboxylic acid metabolic process
myelination
alpha-amino acid catabolic process
glial cell development
ensheathment of neurons
axon ensheathment
regulation of gliogenesis
cellular amino acid catabolic process
glial cell differentiation
alpha-amino acid metabolic process
gliogenesis
organic acid catabolic process
carboxylic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
small molecule catabolic process
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
small molecule biosynthetic process