ATP1B2
Gene Information
- Official Symbol: ATP1B2
- Official Name: ATPase Na+/K+ transporting subunit beta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 482
- UniProt: P14415
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Pfam Domains GO Terms
Pfam Domains
| Na K-ATPase |
GO Terms
| positive regulation of sodium ion export across plasma membrane |
| regulation of sodium ion export across plasma membrane |
| positive regulation of potassium ion import across plasma membrane |
| regulation of potassium ion import |
| sodium:potassium-exchanging ATPase activity |
| sodium:potassium-exchanging ATPase complex |
| sodium ion export across plasma membrane |
| cellular potassium ion homeostasis |
| establishment or maintenance of transmembrane electrochemical gradient |
| cell communication by electrical coupling involved in cardiac conduction |
| cellular sodium ion homeostasis |
| cell communication by electrical coupling |
| positive regulation of sodium ion transmembrane transport |
| membrane repolarization |
| ATPase activator activity |
| positive regulation of potassium ion transmembrane transporter activity |
| potassium ion homeostasis |
| sodium ion homeostasis |
| positive regulation of sodium ion transport |
| positive regulation of potassium ion transmembrane transport |
| export across plasma membrane |
| potassium ion import across plasma membrane |
| cell communication involved in cardiac conduction |
| positive regulation of potassium ion transport |
| positive regulation of ATPase activity |
| regulation of potassium ion transmembrane transporter activity |
| regulation of sodium ion transmembrane transport |
| regulation of cardiac conduction |
| inorganic cation import across plasma membrane |
| inorganic ion import across plasma membrane |
| regulation of potassium ion transmembrane transport |
| ATPase binding |
| regulation of ATPase activity |
| regulation of sodium ion transport |
| sodium ion transmembrane transport |
| cardiac conduction |
| regulation of potassium ion transport |
| import across plasma membrane |
| positive regulation of ion transmembrane transporter activity |
| cellular monovalent inorganic cation homeostasis |
| positive regulation of transporter activity |
| multicellular organismal signaling |
| monovalent inorganic cation homeostasis |
| positive regulation of cation transmembrane transport |
| sodium ion transport |
| positive regulation of ion transmembrane transport |
| potassium ion transmembrane transport |
| potassium ion transport |
| protein stabilization |
| positive regulation of transmembrane transport |
| regulation of heart contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of protein stability |
| regulation of blood circulation |
| apical plasma membrane |
| regulation of cation transmembrane transport |
| leukocyte migration |
| regulation of metal ion transport |
| monovalent inorganic cation transport |
| regulation of membrane potential |
| regulation of ion transmembrane transport |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| regulation of system process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| import into cell |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| cell adhesion |
| biological adhesion |
| ion transmembrane transport |
| cell migration |
| positive regulation of transport |
| export from cell |
| cell motility |
| localization of cell |
| chemical homeostasis |
| regulation of hydrolase activity |
| transmembrane transport |
| locomotion |
| ion transport |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| homeostatic process |
| positive regulation of molecular function |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aminopterin 0.005μM R07 exp335 | -1.95 |
| Zebularine 20μM R07 exp423 | 1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7177
- Expression level (log2 read counts): 0.97
Expression Distribution
ATP1B2 Expression in NALM6 Cells: 0.97
