ATRIP

Entrez Summary: This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 38/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	3/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	1/21
liver	1/20
lung	4/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	1/5

Expression Distribution

K63-linked polyubiquitin modification-dependent protein binding
interstrand cross-link repair
DNA damage checkpoint
DNA integrity checkpoint
regulation of signal transduction by p53 class mediator
cell cycle checkpoint
DNA replication
DNA repair
negative regulation of cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
regulation of cell cycle
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of intracellular signal transduction