ATXN1L

Entrez Summary: N/A
UniProt Summary: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Golgicide-A 2μM R03 exp121	1.71
A-395N 10μM R05 exp219	1.72

positive regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell proliferation
positive regulation of stem cell proliferation
lung alveolus development
intraspecies interaction between organisms
social behavior
regulation of stem cell proliferation
multi-organism behavior
memory
learning
lung development
respiratory tube development
positive regulation of hemopoiesis
respiratory system development
learning or memory
cognition
extracellular matrix organization
extracellular structure organization
dendrite
regulation of hemopoiesis
behavior
brain development
head development
tube development
nucleolus
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
central nervous system development
positive regulation of immune system process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
nervous system process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process