B3GNT6

Official Symbol: B3GNT6
Official Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Aliases and Previous Symbols: N/A
Entrez ID: 192134
UniProt: Q6ZMB0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. [provided by RefSeq, Dec 2016].
UniProt Summary: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

O-glycan processing, core 3
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
poly-N-acetyllactosamine biosynthetic process
poly-N-acetyllactosamine metabolic process
galactosyltransferase activity
acetylgalactosaminyltransferase activity
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
O-glycan processing
cellular polysaccharide metabolic process
polysaccharide metabolic process
aminoglycan biosynthetic process
protein O-linked glycosylation
carbohydrate biosynthetic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane