BAIAP3 [The Human Chemical-Genetic Interaction Map Project]

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======= BAIAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAIAP3
  * **<color #00a2e8>Official Name</color>**: BAI1 associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8938|8938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94812|O94812]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAIAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAIAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604009|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Membr traf MHD|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of dense core granule exocytosis|
|dense core granule maturation|
|secretory granule maturation|
|dense core granule|
|positive regulation of neurotransmitter secretion|
|regulation of synaptic transmission, GABAergic|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|secretory granule organization|
|positive regulation of neurotransmitter transport|
|regulation of calcium ion-dependent exocytosis|
|syntaxin binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|SNARE binding|
|positive regulation of insulin secretion|
|recycling endosome membrane|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|presynapse|
|positive regulation of peptide hormone secretion|
|phospholipid binding|
|regulation of neurotransmitter secretion|
|late endosome membrane|
|positive regulation of hormone secretion|
|regulation of neurotransmitter transport|
|cytosolic transport|
|positive regulation of synaptic transmission|
|early endosome membrane|
|regulation of regulated secretory pathway|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|endosomal transport|
|developmental maturation|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|vesicle organization|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|secretion|
|G protein-coupled receptor signaling pathway|
|intracellular transport|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAIAP3 Expression in NALM6 Cells: 1.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>