BAIAP3

Entrez Summary: This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Membr traf MHD
C2

regulation of dense core granule exocytosis
dense core granule maturation
secretory granule maturation
dense core granule
positive regulation of neurotransmitter secretion
regulation of synaptic transmission, GABAergic
positive regulation of insulin secretion involved in cellular response to glucose stimulus
secretory granule organization
positive regulation of neurotransmitter transport
regulation of calcium ion-dependent exocytosis
syntaxin binding
regulation of insulin secretion involved in cellular response to glucose stimulus
SNARE binding
positive regulation of insulin secretion
recycling endosome membrane
retrograde transport, endosome to Golgi
trans-Golgi network membrane
presynapse
positive regulation of peptide hormone secretion
phospholipid binding
regulation of neurotransmitter secretion
late endosome membrane
positive regulation of hormone secretion
regulation of neurotransmitter transport
cytosolic transport
positive regulation of synaptic transmission
early endosome membrane
regulation of regulated secretory pathway
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of exocytosis
endosomal transport
developmental maturation
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
vesicle organization
regulation of neurotransmitter levels
positive regulation of secretion by cell
endomembrane system organization