BBC3

Gene Information

Official Symbol: BBC3
Official Name: BCL2 binding component 3
Aliases and Previous Symbols: N/A
Entrez ID: 27113
UniProt: Q9BXH1"|"Q96PG8|Q9BXH1"
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13215
Expression level (log2 read counts): 1.69

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	1.71
Olaparib 4μM R08 exp512	1.88
Actinomycin-D 0.001μM R00 exp3	2
GSK626616 14μM R08 exp485	2.28

release of cytochrome c from mitochondria
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of release of cytochrome c from mitochondria
execution phase of apoptosis
positive regulation of establishment of protein localization to mitochondrion
positive regulation of intrinsic apoptotic signaling pathway
apoptotic mitochondrial changes
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
ATPase binding
regulation of membrane permeability
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
mitochondrial membrane organization
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
regulation of intrinsic apoptotic signaling pathway
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
regulation of protein localization to membrane
positive regulation of peptidase activity
mitochondrial transport
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
lysosome
response to endoplasmic reticulum stress
apoptotic signaling pathway
positive regulation of cellular protein localization
positive regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
mitochondrion organization