BCLAF1

Gene Information

Official Symbol: BCLAF1
Official Name: BCL2 associated transcription factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 9774
UniProt: Q9NYF8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 95/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	2/26
breast	7/33
central nervous system	7/56
cervix	0/4
colorectal	4/17
esophagus	3/13
fibroblast	0/1
gastric	3/16
kidney	4/21
liver	0/20
lung	10/75
lymphocyte	4/16
ovary	3/26
pancreas	4/24
peripheral nervous system	6/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1331
Expression level (log2 read counts): 8.55

Expression Distribution

Screen	Score
ML-792 0.2μM R08 exp505	-2.14
L-BMAA 500 to 750μM on day4 R04 exp185	-1.82
PF-06409577 20μM R07 exp389	1.78
Etoposide 0.1μM R05 exp198	2.4

positive regulation of DNA-templated transcription, initiation
regulation of DNA-templated transcription, initiation
positive regulation of intrinsic apoptotic signaling pathway
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
positive regulation of response to DNA damage stimulus
regulation of DNA-templated transcription in response to stress
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
regulation of response to DNA damage stimulus
regulation of apoptotic signaling pathway
nuclear speck
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of cellular response to stress
apoptotic process
cellular response to cytokine stimulus
positive regulation of intracellular signal transduction
programmed cell death
cell death
response to cytokine
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
regulation of apoptotic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction