BCMO1 [The Human Chemical-Genetic Interaction Map Project]

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======= BCMO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCO1
  * **<color #00a2e8>Official Name</color>**: beta-carotene oxygenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53630|53630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAY6|Q9HAY6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCMO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCMO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. {ECO:0000269|PubMed:24668807}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPE65|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin A biosynthetic process|
|beta-carotene metabolic process|
|carotene catabolic process|
|carotene metabolic process|
|carotenoid dioxygenase activity|
|beta-carotene 15,15-monooxygenase activity|
|terpene catabolic process|
|carotenoid metabolic process|
|terpene metabolic process|
|retinal isomerase activity|
|tetraterpenoid metabolic process|
|fat-soluble vitamin biosynthetic process|
|vitamin A metabolic process|
|diterpenoid biosynthetic process|
|isoprenoid catabolic process|
|retinal metabolic process|
|terpenoid biosynthetic process|
|vitamin biosynthetic process|
|isoprenoid biosynthetic process|
|fat-soluble vitamin metabolic process|
|retinol metabolic process|
|cellular aldehyde metabolic process|
|primary alcohol metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|isoprenoid metabolic process|
|cellular lipid catabolic process|
|hormone metabolic process|
|lipid catabolic process|
|alcohol metabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|lipid metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.11|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.73|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCMO1 Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>