BCMO1

Entrez Summary: Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008].
UniProt Summary: Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. {ECO:0000269|PubMed:24668807}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vitamin A biosynthetic process
beta-carotene metabolic process
carotene catabolic process
carotene metabolic process
carotenoid dioxygenase activity
beta-carotene 15,15-monooxygenase activity
terpene catabolic process
carotenoid metabolic process
terpene metabolic process
retinal isomerase activity
tetraterpenoid metabolic process
fat-soluble vitamin biosynthetic process
vitamin A metabolic process
diterpenoid biosynthetic process
isoprenoid catabolic process
retinal metabolic process
terpenoid biosynthetic process
vitamin biosynthetic process
isoprenoid biosynthetic process
fat-soluble vitamin metabolic process
retinol metabolic process
cellular aldehyde metabolic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
vitamin metabolic process
isoprenoid metabolic process
cellular lipid catabolic process
hormone metabolic process
lipid catabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process