BDH2

Entrez Summary: N/A
UniProt Summary: Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). {ECO:0000250, ECO:0000269|PubMed:16380372}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

siderophore biosynthetic process
siderophore metabolic process
3-hydroxybutyrate dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
ketone body biosynthetic process
cellular ketone body metabolic process
ketone body metabolic process
nonribosomal peptide biosynthetic process
secondary metabolite biosynthetic process
heme metabolic process
porphyrin-containing compound metabolic process
NAD binding
secondary metabolic process
fatty acid beta-oxidation
tetrapyrrole metabolic process
pigment metabolic process
fatty acid oxidation
lipid oxidation
iron ion homeostasis
fatty acid derivative biosynthetic process
fatty acid catabolic process
monocarboxylic acid catabolic process
transition metal ion homeostasis
fatty acid derivative metabolic process
cellular lipid catabolic process
lipid modification
cofactor biosynthetic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
peptide biosynthetic process
generation of precursor metabolites and energy
small molecule catabolic process
cofactor metabolic process
drug metabolic process
amide biosynthetic process
peptide metabolic process
monocarboxylic acid metabolic process
small molecule biosynthetic process