BGLAP [The Human Chemical-Genetic Interaction Map Project]

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======= BGLAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BGLAP
  * **<color #00a2e8>Official Name</color>**: bone gamma-carboxyglutamate protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=632|632]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02818|P02818]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BGLAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BGLAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gla|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of bone|
|hydroxyapatite binding|
|response to hydroxyisoflavone|
|response to vitamin K|
|response to phenylpropanoid|
|response to gravity|
|cellular response to vitamin D|
|osteoblast development|
|cellular response to vitamin|
|response to vitamin D|
|response to testosterone|
|regulation of bone resorption|
|bone mineralization|
|regulation of bone remodeling|
|response to zinc ion|
|rough endoplasmic reticulum|
|cell aging|
|response to activity|
|regulation of osteoclast differentiation|
|cellular response to nutrient|
|regulation of cellular response to insulin stimulus|
|regulation of tissue remodeling|
|regulation of bone mineralization|
|response to estrogen|
|response to vitamin|
|biomineralization|
|regulation of biomineralization|
|biomineral tissue development|
|regulation of biomineral tissue development|
|Golgi lumen|
|regulation of myeloid leukocyte differentiation|
|odontogenesis|
|osteoblast differentiation|
|response to ethanol|
|perikaryon|
|vesicle|
|response to glucocorticoid|
|response to corticosteroid|
|regulation of ossification|
|structural molecule activity|
|response to ketone|
|bone development|
|response to mechanical stimulus|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|response to nutrient|
|regulation of myeloid cell differentiation|
|response to alcohol|
|cellular response to nutrient levels|
|ossification|
|cellular response to extracellular stimulus|
|regulation of leukocyte differentiation|
|aging|
|endoplasmic reticulum lumen|
|response to antibiotic|
|response to steroid hormone|
|cellular response to external stimulus|
|response to metal ion|
|Golgi vesicle transport|
|dendrite|
|regulation of hemopoiesis|
|skeletal system development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to toxic substance|
|cellular response to lipid|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|calcium ion binding|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|response to drug|
|cellular response to oxygen-containing compound|
|response to abiotic stimulus|
|response to endogenous stimulus|
|intracellular transport|
|response to oxygen-containing compound|
|extracellular space|
|cell development|
|regulation of immune system process|
|tissue development|
|regulation of cell differentiation|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.94|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BGLAP Expression in NALM6 Cells: -0.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>