BGLAP

Entrez Summary: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015].
UniProt Summary: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

structural constituent of bone
hydroxyapatite binding
response to hydroxyisoflavone
response to vitamin K
response to phenylpropanoid
response to gravity
cellular response to vitamin D
osteoblast development
cellular response to vitamin
response to vitamin D
response to testosterone
regulation of bone resorption
bone mineralization
regulation of bone remodeling
response to zinc ion
rough endoplasmic reticulum
cell aging
response to activity
regulation of osteoclast differentiation
cellular response to nutrient
regulation of cellular response to insulin stimulus
regulation of tissue remodeling
regulation of bone mineralization
response to estrogen
response to vitamin
biomineralization
regulation of biomineralization
biomineral tissue development
regulation of biomineral tissue development
Golgi lumen
regulation of myeloid leukocyte differentiation
odontogenesis
osteoblast differentiation
response to ethanol
perikaryon
vesicle
response to glucocorticoid
response to corticosteroid
regulation of ossification
structural molecule activity