BHLHA15 [The Human Chemical-Genetic Interaction Map Project]

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======= BHLHA15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BHLHA15
  * **<color #00a2e8>Official Name</color>**: basic helix-loop-helix family member a15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=168620|168620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTS1|Q7RTS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BHLHA15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BHLHA15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608606|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250|UniProtKB:Q9QYC3}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular distribution of mitochondria|
|mitochondrion distribution|
|negative regulation of myotube differentiation|
|mitochondrial calcium ion transmembrane transport|
|negative regulation of striated muscle cell differentiation|
|cellular response to glucose starvation|
|mitochondrion localization|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|regulation of striated muscle cell differentiation|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|Golgi organization|
|calcium-mediated signaling|
|cellular response to topologically incorrect protein|
|cellular response to starvation|
|regulation of muscle cell differentiation|
|cell maturation|
|response to unfolded protein|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to topologically incorrect protein|
|response to starvation|
|calcium ion transmembrane transport|
|cellular response to nutrient levels|
|developmental maturation|
|calcium ion transport|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|divalent metal ion transport|
|divalent inorganic cation transport|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|endomembrane system organization|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to nutrient levels|
|response to extracellular stimulus|
|inorganic cation transmembrane transport|
|organelle localization|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|negative regulation of cell differentiation|
|cation transport|
|protein homodimerization activity|
|negative regulation of developmental process|
|ion transmembrane transport|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.02|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.82|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BHLHA15 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>