BHLHA15

Entrez Summary: N/A
UniProt Summary: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250|UniProtKB:Q9QYC3}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intracellular distribution of mitochondria
mitochondrion distribution
negative regulation of myotube differentiation
mitochondrial calcium ion transmembrane transport
negative regulation of striated muscle cell differentiation
cellular response to glucose starvation
mitochondrion localization
negative regulation of muscle cell differentiation
regulation of myotube differentiation
regulation of striated muscle cell differentiation
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
Golgi organization
calcium-mediated signaling
cellular response to topologically incorrect protein
cellular response to starvation
regulation of muscle cell differentiation
cell maturation
response to unfolded protein
glucose homeostasis
carbohydrate homeostasis
response to topologically incorrect protein
response to starvation
calcium ion transmembrane transport
cellular response to nutrient levels
developmental maturation
calcium ion transport
response to endoplasmic reticulum stress
cellular response to extracellular stimulus
divalent metal ion transport
divalent inorganic cation transport
RNA polymerase II regulatory region sequence-specific DNA binding
cellular response to external stimulus
second-messenger-mediated signaling
endomembrane system organization
mitochondrion organization
DNA-binding transcription activator activity, RNA polymerase II-specific
response to nutrient levels
response to extracellular stimulus
inorganic cation transmembrane transport