BIRC7

Gene Information

Official Symbol: BIRC7
Official Name: baculoviral IAP repeat containing 7
Aliases and Previous Symbols: N/A
Entrez ID: 79444
UniProt: Q96CA5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013].
UniProt Summary: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. {ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:16729033, ECO:0000269|PubMed:17294084, ECO:0000269|PubMed:18034418}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4521
Expression level (log2 read counts): -4.27

Expression Distribution

Screen	Score
Rotenone 2μM R00 exp33	-1.89
Actinomycin-D 0.001μM R00 exp3	-1.83

regulation of natural killer cell apoptotic process
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
inhibition of cysteine-type endopeptidase activity
zymogen inhibition
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
negative regulation of protein processing
cysteine-type endopeptidase inhibitor activity
negative regulation of protein maturation
activation of JUN kinase activity
regulation of lymphocyte apoptotic process
regulation of protein processing
regulation of protein maturation
positive regulation of JUN kinase activity
JNK cascade
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of leukocyte apoptotic process
regulation of JUN kinase activity
negative regulation of cysteine-type endopeptidase activity
stress-activated MAPK cascade
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
microtubule organizing center
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
regulation of protein ubiquitination
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
ubiquitin-protein transferase activity
negative regulation of peptidase activity
positive regulation of MAP kinase activity
activation of protein kinase activity