BMF
Gene Information
- Official Symbol: BMF
- Official Name: Bcl2 modifying factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 90427
- UniProt: Q96LC9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| positive regulation of protein homooligomerization |
| anoikis |
| mitochondrial outer membrane permeabilization |
| positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| mitochondrial outer membrane permeabilization involved in programmed cell death |
| regulation of protein homooligomerization |
| positive regulation of mitochondrial membrane permeability |
| protein insertion into mitochondrial membrane |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| positive regulation of membrane permeability |
| positive regulation of protein oligomerization |
| positive regulation of release of cytochrome c from mitochondria |
| myosin complex |
| protein insertion into membrane |
| regulation of protein oligomerization |
| regulation of release of cytochrome c from mitochondria |
| positive regulation of intrinsic apoptotic signaling pathway |
| apoptotic mitochondrial changes |
| establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane permeability |
| protein localization to mitochondrion |
| regulation of membrane permeability |
| cellular response to UV |
| negative regulation of autophagy |
| acrosomal vesicle |
| cellular response to light stimulus |
| positive regulation of mitochondrion organization |
| mitochondrial membrane organization |
| response to UV |
| regulation of intrinsic apoptotic signaling pathway |
| mitochondrial outer membrane |
| positive regulation of apoptotic signaling pathway |
| cellular response to radiation |
| regulation of mitochondrion organization |
| mitochondrial transport |
| positive regulation of protein complex assembly |
| negative regulation of cellular catabolic process |
| establishment of protein localization to membrane |
| apoptotic signaling pathway |
| response to light stimulus |
| negative regulation of catabolic process |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of autophagy |
| regulation of apoptotic signaling pathway |
| establishment of protein localization to organelle |
| response to radiation |
| mitochondrion organization |
| regulation of protein complex assembly |
| protein localization to membrane |
| positive regulation of cellular component biogenesis |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| protein localization to organelle |
| regulation of cellular catabolic process |
| membrane organization |
| apoptotic process |
| regulation of cellular component biogenesis |
| regulation of catabolic process |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| cell death |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC0946 7μM R03 exp151 | -2.35 |
| MS023 7μM R03 exp135 | 2.03 |
| JQ1 0.8μM R08 exp435 | 3.64 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4229
- Expression level (log2 read counts): 1.39
Expression Distribution
BMF Expression in NALM6 Cells: 1.39
