BMP4
Gene Information
- Official Symbol: BMP4
- Official Name: bone morphogenetic protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 652
- UniProt: P12644
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].
- UniProt Summary: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| specification of ureteric bud anterior/posterior symmetry |
| positive regulation of cell proliferation involved in outflow tract morphogenesis |
| intermediate mesodermal cell differentiation |
| specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway |
| negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway |
| negative regulation of branch elongation involved in ureteric bud branching |
| BMP signaling pathway involved in nephric duct formation |
| regulation of transcription from RNA polymerase II promoter involved in mesonephros development |
| pulmonary artery endothelial tube morphogenesis |
| BMP signaling pathway involved in ureter morphogenesis |
| apoptotic process involved in endocardial cushion morphogenesis |
| intermediate mesoderm morphogenesis |
| negative regulation of mesenchymal cell proliferation involved in ureter development |
| regulation of metanephric S-shaped body morphogenesis |
| regulation of cardiac muscle fiber development |
| positive regulation of cardiac muscle fiber development |
| intermediate mesoderm formation |
| anterior/posterior pattern specification involved in ureteric bud development |
| mesenchymal cell proliferation involved in ureter development |
| negative regulation of metanephric comma-shaped body morphogenesis |
| negative regulation of metanephric S-shaped body morphogenesis |
| cardiac jelly development |
| renal system segmentation |
| regulation of metanephric comma-shaped body morphogenesis |
| ureter epithelial cell differentiation |
| bud dilation involved in lung branching |
| BMP signaling pathway involved in renal system segmentation |
| intermediate mesoderm development |
| heart induction |
| anterior/posterior pattern specification involved in kidney development |
| regulation of transcription from RNA polymerase II promoter involved in kidney development |
| epithelial cell proliferation involved in lung morphogenesis |
| negative regulation of branching involved in ureteric bud morphogenesis |
| endodermal-mesodermal cell signaling involved in heart induction |
| BMP signaling pathway involved in heart induction |
| endodermal-mesodermal cell signaling |
| regulation of cell proliferation involved in outflow tract morphogenesis |
| pattern specification involved in mesonephros development |
| cloacal septation |
| specification of animal organ position |
| negative regulation of glomerulus development |
| negative regulation of glomerular mesangial cell proliferation |
| tendon cell differentiation |
| mesodermal cell fate determination |
| tendon formation |
| regulation of mesenchymal cell proliferation involved in ureter development |
| ureter smooth muscle development |
| mesenchymal cell proliferation involved in ureteric bud development |
| positive regulation of neural crest cell differentiation |
| positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| ureter smooth muscle cell differentiation |
| deltoid tuberosity development |
| ureter urothelium development |
| cell proliferation involved in mesonephros development |
| negative regulation of cell proliferation involved in heart morphogenesis |
| negative regulation of immature T cell proliferation in thymus |
| lens induction in camera-type eye |
| regulation of branch elongation involved in ureteric bud branching |
| apoptotic process involved in heart morphogenesis |
| positive regulation of branching involved in lung morphogenesis |
| negative regulation of mesonephros development |
| cloaca development |
| regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| negative regulation of prostatic bud formation |
| negative regulation of cell proliferation involved in kidney development |
| regulation of neural crest cell differentiation |
| glomerular capillary formation |
| negative regulation of immature T cell proliferation |
| nephric duct formation |
| glomerulus vasculature morphogenesis |
| trachea formation |
| common-partner SMAD protein phosphorylation |
| epithelial-mesenchymal cell signaling |
| regulation of immature T cell proliferation in thymus |
| BMP signaling pathway involved in heart development |
| regulation of prostatic bud formation |
| regulation of branching involved in lung morphogenesis |
| tendon development |
| pulmonary artery morphogenesis |
| regulation of branching involved in prostate gland morphogenesis |
| muscular septum morphogenesis |
| positive regulation of cell proliferation involved in heart morphogenesis |
| bud elongation involved in lung branching |
| renal system vasculature morphogenesis |
| blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| mesenchymal to epithelial transition involved in metanephros morphogenesis |
| kidney vasculature morphogenesis |
| negative regulation of thymocyte apoptotic process |
| ureter morphogenesis |
| mammary gland formation |
| mesenchymal cell differentiation involved in renal system development |
| mesenchymal cell differentiation involved in kidney development |
| negative regulation of T cell differentiation in thymus |
| regulation of immature T cell proliferation |
| metanephric collecting duct development |
| pharyngeal arch artery morphogenesis |
| glomerulus morphogenesis |
| negative regulation of mesenchymal cell proliferation |
| heart field specification |
| pattern specification involved in kidney development |
| renal system pattern specification |
| cranial suture morphogenesis |
| secondary heart field specification |
| negative regulation of metanephros development |
| glomerular visceral epithelial cell development |
| membranous septum morphogenesis |
| regulation of glomerular mesangial cell proliferation |
| bronchus development |
| branching involved in prostate gland morphogenesis |
| glomerular epithelial cell development |
| cell proliferation involved in kidney development |
| positive regulation of production of miRNAs involved in gene silencing by miRNA |
| metanephric renal vesicle morphogenesis |
| BMP receptor binding |
| embryonic skeletal joint morphogenesis |
| trachea morphogenesis |
| nephric duct morphogenesis |
| regulation of thymocyte apoptotic process |
| positive regulation of SMAD protein signal transduction |
| endothelial tube morphogenesis |
| collecting duct development |
| lymphoid progenitor cell differentiation |
| morphogenesis of an endothelium |
| renal vesicle morphogenesis |
| telencephalon regionalization |
| renal vesicle development |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| co-receptor binding |
| mesodermal cell fate commitment |
| epithelial to mesenchymal transition involved in endocardial cushion formation |
| heart formation |
| regulation of transcription from RNA polymerase II promoter involved in heart development |
| regulation of cell proliferation involved in kidney development |
| embryonic skeletal joint development |
| regulation of odontogenesis of dentin-containing tooth |
| type B pancreatic cell development |
| mesenchymal to epithelial transition |
| organ induction |
| regulation of glomerulus development |
| specification of animal organ identity |
| ureter development |
| apoptotic process involved in morphogenesis |
| positive regulation of endothelial cell differentiation |
| negative regulation of kidney development |
| negative regulation of morphogenesis of an epithelium |
| renal filtration cell differentiation |
| nephric duct development |
| mesenchymal cell proliferation |
| glomerular visceral epithelial cell differentiation |
| glomerular epithelial cell differentiation |
| monocyte differentiation |
| branch elongation of an epithelium |
| smooth muscle tissue development |
| cell differentiation involved in metanephros development |
| dorsal/ventral neural tube patterning |
| mononuclear cell differentiation |
| regulation of cell proliferation involved in heart morphogenesis |
| pulmonary valve morphogenesis |
| craniofacial suture morphogenesis |
| kidney mesenchyme development |
| glomerulus vasculature development |
| negative regulation of T cell apoptotic process |
| regulation of production of miRNAs involved in gene silencing by miRNA |
| type B pancreatic cell differentiation |
| glandular epithelial cell development |
| positive regulation of cardiac muscle cell differentiation |
| trachea development |
| enteroendocrine cell differentiation |
| endocardial cushion formation |
| kidney vasculature development |
| regulation of production of small RNA involved in gene silencing by RNA |
| metanephric nephron morphogenesis |
| glomerular epithelium development |
| cardiac right ventricle morphogenesis |
| renal system vasculature development |
| positive regulation of stem cell differentiation |
| pulmonary valve development |
| prostate gland epithelium morphogenesis |
| negative regulation of chondrocyte differentiation |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of SMAD protein signal transduction |
| lens morphogenesis in camera-type eye |
| positive regulation of gene silencing by miRNA |
| regulation of metanephros development |
| endothelial cell proliferation |
| cell surface receptor signaling pathway involved in heart development |
| positive regulation of epidermal cell differentiation |
| regulation of T cell differentiation in thymus |
| positive regulation of posttranscriptional gene silencing |
| prostate gland morphogenesis |
| macrophage differentiation |
| forebrain regionalization |
| positive regulation of collagen biosynthetic process |
| negative regulation of myoblast differentiation |
| regulation of mesonephros development |
| regulation of odontogenesis |
| positive regulation of collagen metabolic process |
| pharyngeal system development |
| mesodermal cell differentiation |
| negative regulation of embryonic development |
| epithelial tube branching involved in lung morphogenesis |
| developmental induction |
| axis elongation |
| apoptotic process involved in development |
| metanephros morphogenesis |
| cardiac epithelial to mesenchymal transition |
| negative regulation of lymphocyte apoptotic process |
| negative regulation of cartilage development |
| aortic valve morphogenesis |
| outflow tract septum morphogenesis |
| regulation of cell fate commitment |
| replacement ossification |
| embryonic hindlimb morphogenesis |
| positive regulation of cardiocyte differentiation |
| cell fate commitment involved in formation of primary germ layer |
| endochondral ossification |
| epithelial cell differentiation involved in kidney development |
| lung epithelium development |
| regulation of smooth muscle cell differentiation |
| metanephric nephron development |
| aortic valve development |
| smooth muscle cell differentiation |
| positive regulation of BMP signaling pathway |
| regulation of T cell apoptotic process |
| regulation of mesenchymal cell proliferation |
| positive regulation of cartilage development |
| regulation of endothelial cell differentiation |
| negative regulation of animal organ morphogenesis |
| neural tube patterning |
| animal organ formation |
| positive regulation of morphogenesis of an epithelium |
| regulation of collagen biosynthetic process |
| endocardial cushion morphogenesis |
| regulation of cardiac muscle cell differentiation |
| hindlimb morphogenesis |
| chemoattractant activity |
| regulation of animal organ formation |
| semi-lunar valve development |
| endocrine pancreas development |
| glandular epithelial cell differentiation |
| positive regulation of bone mineralization |
| cell fate determination |
| positive regulation of epidermis development |
| regulation of collagen metabolic process |
| positive regulation of kidney development |
| negative regulation of mitotic nuclear division |
| regulation of heart morphogenesis |
| cell differentiation involved in kidney development |
| lung alveolus development |
| prostate gland development |
| ventricular septum morphogenesis |
| transforming growth factor beta receptor binding |
| pituitary gland development |
| regulation of pri-miRNA transcription by RNA polymerase II |
| mammary gland morphogenesis |
| negative regulation of T cell differentiation |
| endocardial cushion development |
| lung morphogenesis |
| branching involved in ureteric bud morphogenesis |
| positive regulation of cardiac muscle tissue development |
| embryonic cranial skeleton morphogenesis |
| coronary vasculature development |
| negative regulation of leukocyte apoptotic process |
| positive regulation of epithelial to mesenchymal transition |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of nuclear division |
| negative regulation of striated muscle tissue development |
| positive chemotaxis |
| digestive tract morphogenesis |
| columnar/cuboidal epithelial cell development |
| negative regulation of muscle organ development |
| mesenchyme morphogenesis |
| regulation of cardiocyte differentiation |
| anterior/posterior axis specification |
| negative regulation of muscle tissue development |
| glomerulus development |
| regulation of chondrocyte differentiation |
| inner ear receptor cell differentiation |
| heart valve morphogenesis |
| regulation of lymphocyte apoptotic process |
| regulation of myoblast differentiation |
| ureteric bud morphogenesis |
| negative regulation of lymphocyte differentiation |
| activation of MAPKK activity |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of protein import into nucleus |
| SMAD protein signal transduction |
| negative regulation of reproductive process |
| regulation of morphogenesis of a branching structure |
| sprouting angiogenesis |
| mechanoreceptor differentiation |
| positive regulation of striated muscle cell differentiation |
| positive regulation of osteoblast differentiation |
| regulation of protein import |
| positive regulation of epithelial cell differentiation |
| negative regulation of T cell proliferation |
| heart valve development |
| regulation of pathway-restricted SMAD protein phosphorylation |
| embryonic digit morphogenesis |
| regulation of epidermal cell differentiation |
| artery morphogenesis |
| nephron tubule morphogenesis |
| neuron fate commitment |
| cranial skeletal system development |
| nephron epithelium morphogenesis |
| mesoderm formation |
| nephron morphogenesis |
| renal tubule morphogenesis |
| positive regulation of striated muscle tissue development |
| mesoderm morphogenesis |
| positive regulation of muscle organ development |
| regulation of cartilage development |
| epithelial to mesenchymal transition |
| positive regulation of muscle tissue development |
| smoothened signaling pathway |
| endochondral bone morphogenesis |
| ventricular septum development |
| pancreas development |
| cardiac ventricle morphogenesis |
| outflow tract morphogenesis |
| cardiac septum morphogenesis |
| endoderm development |
| negative regulation of mononuclear cell proliferation |
| negative regulation of MAP kinase activity |
| negative regulation of lymphocyte proliferation |
| regulation of bone mineralization |
| diencephalon development |
| nephron tubule development |
| lens development in camera-type eye |
| negative regulation of leukocyte proliferation |
| regulation of cardiac muscle tissue development |
| muscle tissue morphogenesis |
| erythrocyte differentiation |
| renal tubule development |
| dorsal/ventral pattern formation |
| positive regulation of animal organ morphogenesis |
| chondrocyte differentiation |
| regulation of leukocyte apoptotic process |
| odontogenesis of dentin-containing tooth |
| metanephros development |
| regulation of epithelial to mesenchymal transition |
| positive regulation of ossification |
| kidney morphogenesis |
| positive regulation of smooth muscle cell proliferation |
| ureteric bud development |
| regulation of epidermis development |
| axis specification |
| artery development |
| mesonephric tubule development |
| epithelial cell proliferation |
| hematopoietic progenitor cell differentiation |
| muscle organ morphogenesis |
| regulation of gene silencing by miRNA |
| mesonephric epithelium development |
| positive regulation of muscle cell differentiation |
| regulation of BMP signaling pathway |
| cardiac muscle cell differentiation |
| post-embryonic development |
| erythrocyte homeostasis |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| BMP signaling pathway |
| neural tube closure |
| mesonephros development |
| tube closure |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| embryonic skeletal system morphogenesis |
| positive regulation of protein binding |
| positive regulation of endothelial cell proliferation |
| segmentation |
| endothelium development |
| columnar/cuboidal epithelial cell differentiation |
| nephron epithelium development |
| primary neural tube formation |
| gland morphogenesis |
| positive regulation of endothelial cell migration |
| negative regulation of leukocyte differentiation |
| negative regulation of extrinsic apoptotic signaling pathway |
| regulation of striated muscle cell differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to BMP stimulus |
| response to BMP |
| negative regulation of developmental growth |
| regulation of nucleocytoplasmic transport |
| neural tube formation |
| myeloid cell homeostasis |
| cardiac septum development |
| negative regulation of T cell activation |
| renal system process |
| formation of primary germ layer |
| myeloid leukocyte differentiation |
| camera-type eye morphogenesis |
| regulation of osteoblast differentiation |
| bone morphogenesis |
| developmental growth involved in morphogenesis |
| negative regulation of vasculature development |
| cardiocyte differentiation |
| regulation of protein localization to nucleus |
| regulation of stem cell differentiation |
| steroid hormone mediated signaling pathway |
| odontogenesis |
| negative regulation of leukocyte cell-cell adhesion |
| endocrine system development |
| embryonic epithelial tube formation |
| mesoderm development |
| nephron development |
| specification of symmetry |
| negative regulation of epithelial cell proliferation |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| cardiac chamber morphogenesis |
| embryonic skeletal system development |
| osteoblast differentiation |
| cardiac ventricle development |
| mammary gland development |
| kidney epithelium development |
| regulation of embryonic development |
| regulation of endothelial cell proliferation |
| regulation of gene silencing |
| branching morphogenesis of an epithelial tube |
| digestive tract development |
| regulation of striated muscle tissue development |
| epithelial tube formation |
| negative regulation of protein serine/threonine kinase activity |
| regulation of smooth muscle cell proliferation |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| positive regulation of epithelial cell migration |
| regulation of epithelial cell differentiation |
| digestive system development |
| negative regulation of lymphocyte activation |
| morphogenesis of embryonic epithelium |
| tube formation |
| eye morphogenesis |
| appendage morphogenesis |
| limb morphogenesis |
| regulation of muscle cell differentiation |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of T cell proliferation |
| mesenchymal cell differentiation |
| regulation of endothelial cell migration |
| gastrulation |
| morphogenesis of a branching epithelium |
| neural tube development |
| regulation of reproductive process |
| cardiac muscle tissue development |
| protein localization to nucleus |
| growth factor activity |
| negative regulation of MAPK cascade |
| morphogenesis of a branching structure |
| regulation of mitotic nuclear division |
| regulation of lymphocyte differentiation |
| lung development |
| heparin binding |
| hormone-mediated signaling pathway |
| cardiac chamber development |
| cartilage development |
| respiratory tube development |
| cytokine activity |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| positive regulation of binding |
| regulation of morphogenesis of an epithelium |
| appendage development |
| limb development |
| cellular response to steroid hormone stimulus |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| regulation of nuclear division |
| epithelial cell development |
| inner ear development |
| respiratory system development |
| negative regulation of cell activation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| homeostasis of number of cells |
| bone development |
| striated muscle cell differentiation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| anterior/posterior pattern specification |
| regulation of protein binding |
| myeloid cell differentiation |
| regulation of epithelial cell migration |
| ear development |
| mesenchyme development |
| regulation of leukocyte proliferation |
| connective tissue development |
| negative regulation of protein kinase activity |
| negative regulation of apoptotic signaling pathway |
| regulation of intracellular protein transport |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| negative regulation of growth |
| muscle cell differentiation |
| cell fate commitment |
| negative regulation of kinase activity |
| heart morphogenesis |
| germ cell development |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| telencephalon development |
| positive regulation of MAP kinase activity |
| ossification |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| negative regulation of transferase activity |
| renal system development |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| regulation of ERK1 and ERK2 cascade |
| muscle organ development |
| regulation of leukocyte cell-cell adhesion |
| muscle tissue development |
| endoplasmic reticulum lumen |
| epithelial tube morphogenesis |
| negative regulation of mitotic cell cycle |
| camera-type eye development |
| angiogenesis |
| regulation of T cell activation |
| urogenital system development |
| regulation of vasculature development |
| negative regulation of cell cycle process |
| response to steroid hormone |
| activation of protein kinase activity |
| regulation of developmental growth |
| leukocyte differentiation |
| regionalization |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of intracellular transport |
| cellular process involved in reproduction in multicellular organism |
| eye development |
| visual system development |
| post-translational protein modification |
| sensory system development |
| positive regulation of neuron differentiation |
| negative regulation of organelle organization |
| regulation of binding |
| forebrain development |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| gland development |
| reproductive structure development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| positive regulation of neurogenesis |
| muscle structure development |
| blood vessel development |
| skeletal system development |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| vasculature development |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| cellular response to lipid |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| sensory organ development |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell population proliferation |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| epithelial cell differentiation |
| gamete generation |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| protein localization to organelle |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| head development |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| multi-organism reproductive process |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell death |
| negative regulation of protein metabolic process |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9581
- Expression level (log2 read counts): 0.93
Expression Distribution
BMP4 Expression in NALM6 Cells: 0.93
