BMP7 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BMP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP7
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=655|655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18075|P18075]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nephrogenic mesenchyme morphogenesis|
|allantois development|
|positive regulation of neural crest cell differentiation|
|kidney mesenchymal cell proliferation|
|metanephric mesenchyme morphogenesis|
|negative regulation of glomerular mesangial cell proliferation|
|monocyte aggregation|
|negative regulation of glomerulus development|
|positive regulation of hyaluranon cable assembly|
|nephrogenic mesenchyme development|
|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|
|neural fold elevation formation|
|metanephric mesenchymal cell proliferation involved in metanephros development|
|regulation of hyaluranon cable assembly|
|kidney mesenchyme morphogenesis|
|regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|
|negative regulation of prostatic bud formation|
|negative regulation of somatic stem cell population maintenance|
|negative regulation of cell proliferation involved in kidney development|
|regulation of neural crest cell differentiation|
|negative regulation of apoptotic process involved in development|
|negative regulation of apoptotic process involved in morphogenesis|
|regulation of branching involved in prostate gland morphogenesis|
|regulation of prostatic bud formation|
|regulation of somatic stem cell population maintenance|
|negative regulation of stem cell population maintenance|
|neural fold formation|
|chorio-allantoic fusion|
|cell proliferation involved in metanephros development|
|pericardium morphogenesis|
|extraembryonic membrane development|
|cell proliferation involved in kidney development|
|regulation of removal of superoxide radicals|
|regulation of glomerular mesangial cell proliferation|
|negative regulation of mesenchymal cell apoptotic process|
|leukocyte aggregation|
|BMP receptor binding|
|embryonic skeletal joint morphogenesis|
|regulation of apoptotic process involved in morphogenesis|
|regulation of apoptotic process involved in development|
|regulation of mesenchymal cell apoptotic process|
|metanephric mesenchyme development|
|regulation of cell proliferation involved in kidney development|
|embryonic skeletal joint development|
|regulation of glomerulus development|
|negative regulation of morphogenesis of an epithelium|
|negative regulation of kidney development|
|positive regulation of heterotypic cell-cell adhesion|
|mesenchymal cell proliferation|
|branching involved in salivary gland morphogenesis|
|kidney mesenchyme development|
|morphogenesis of an epithelial fold|
|pericardium development|
|endocardial cushion formation|
|positive regulation of stem cell differentiation|
|labyrinthine layer morphogenesis|
|negative regulation of NIK/NF-kappaB signaling|
|negative regulation of striated muscle cell apoptotic process|
|pharyngeal system development|
|regulation of heterotypic cell-cell adhesion|
|embryonic placenta morphogenesis|
|negative regulation of embryonic development|
|embryonic camera-type eye morphogenesis|
|regulation of stem cell population maintenance|
|positive regulation of cardiocyte differentiation|
|salivary gland morphogenesis|
|positive regulation of peptidyl-threonine phosphorylation|
|response to vitamin D|
|heart trabecula morphogenesis|
|salivary gland development|
|regulation of superoxide metabolic process|
|negative regulation of animal organ morphogenesis|
|regulation of response to reactive oxygen species|
|embryonic eye morphogenesis|
|endocardial cushion morphogenesis|
|regulation of animal organ formation|
|embryonic camera-type eye development|
|negative regulation of muscle cell apoptotic process|
|positive regulation of bone mineralization|
|regulation of striated muscle cell apoptotic process|
|negative regulation of mitotic nuclear division|
|regulation of heart morphogenesis|
|transforming growth factor beta receptor binding|
|negative regulation of Notch signaling pathway|
|endocardial cushion development|
|exocrine system development|
|regulation of peptidyl-threonine phosphorylation|
|trabecula morphogenesis|
|labyrinthine layer development|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|negative regulation of nuclear division|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|morphogenesis of an epithelial sheet|
|mesenchyme morphogenesis|
|regulation of cardiocyte differentiation|
|leukocyte cell-cell adhesion|
|regulation of kidney development|
|negative regulation of reproductive process|
|SMAD protein signal transduction|
|regulation of morphogenesis of a branching structure|
|positive regulation of osteoblast differentiation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|embryonic pattern specification|
|mesoderm formation|
|regulation of muscle cell apoptotic process|
|mesoderm morphogenesis|
|epithelial to mesenchymal transition|
|positive regulation of dendrite development|
|cardiac septum morphogenesis|
|negative regulation of MAP kinase activity|
|regulation of bone mineralization|
|regulation of cellular response to oxidative stress|
|positive regulation of animal organ morphogenesis|
|negative regulation of NF-kappaB transcription factor activity|
|odontogenesis of dentin-containing tooth|
|regulation of epithelial to mesenchymal transition|
|metanephros development|
|positive regulation of ossification|
|regulation of response to oxidative stress|
|ureteric bud development|
|mesonephric tubule development|
|embryonic placenta development|
|response to vitamin|
|mesonephric epithelium development|
|BMP signaling pathway|
|mesonephros development|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|embryonic skeletal system morphogenesis|
|primary neural tube formation|
|gland morphogenesis|
|regulation of Notch signaling pathway|
|dendrite development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|neural tube formation|
|cardiac septum development|
|regulation of NIK/NF-kappaB signaling|
|formation of primary germ layer|
|camera-type eye morphogenesis|
|regulation of osteoblast differentiation|
|negative regulation of vasculature development|
|regulation of stem cell differentiation|
|steroid hormone mediated signaling pathway|
|odontogenesis|
|embryonic epithelial tube formation|
|mesoderm development|
|nephron development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|cardiac chamber morphogenesis|
|embryonic skeletal system development|
|kidney epithelium development|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|negative regulation of protein serine/threonine kinase activity|
|response to estradiol|
|vesicle|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|tube formation|
|regulation of dendrite development|
|appendage morphogenesis|
|limb morphogenesis|
|hindbrain development|
|placenta development|
|mesenchymal cell differentiation|
|gastrulation|
|morphogenesis of a branching epithelium|
|neural tube development|
|negative regulation of DNA-binding transcription factor activity|
|regulation of reproductive process|
|cardiac muscle tissue development|
|protein localization to nucleus|
|growth factor activity|
|negative regulation of MAPK cascade|
|regulation of mitotic nuclear division|
|morphogenesis of a branching structure|
|cardiac chamber development|
|hormone-mediated signaling pathway|
|heparin binding|
|cartilage development|
|cytokine activity|
|regulation of reactive oxygen species metabolic process|
|appendage development|
|regulation of morphogenesis of an epithelium|
|limb development|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|regulation of ossification|
|regulation of nuclear division|
|cellular response to decreased oxygen levels|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to nutrient|
|cellular response to oxygen levels|
|mesenchyme development|
|connective tissue development|
|negative regulation of neuron differentiation|
|negative regulation of protein kinase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|negative regulation of kinase activity|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|ossification|
|neuron projection guidance|
|kidney development|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|renal system development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|muscle tissue development|
|negative regulation of mitotic cell cycle|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of cell cycle process|
|response to steroid hormone|
|negative regulation of cell development|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|positive regulation of neuron differentiation|
|axonogenesis|
|negative regulation of organelle organization|
|in utero embryonic development|
|response to oxygen levels|
|positive regulation of cell projection organization|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|axon development|
|gland development|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|negative regulation of phosphorylation|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|sensory organ development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|protein localization to organelle|
|regulation of cellular response to stress|
|brain development|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3497
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP7 Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>